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Changes in anatomy over the course of treatment

10 H&N – oropharingeal ca pts, IMRT

Three radiation oncologists delineating OARs, three contouring

sessions one week apart

Mean difference in total volume for each OAR was 1 cm3 for

each OAR.

Considerable spatial differences in contours, ipsilateral parotis

and pharingeal constrictors showing most variability.

Despite substantial differences in OAR contours,

optimization was barely affected with less than a 1 Gy

difference in dose

(Feng

et al

, 2012)