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Criteria for Vetting Methods to be Considered:
The Stakeholder Panel on Strategic Food Analytical Methods previously issued a Call for Methods for St.
John’s wort based upon the criteria set forth in the approved Standard Method Performance
Requirements (SMPRs). Sixteen (16) methods were received via method authors and publication
searches.
Criteria for Vetting Experts and Selection Process:
The Stakeholder Panel on Strategic Food Analytical Methods previously issued a Call for Experts for St.
John’s wort. The following names were submitted to the AOAC Official Methods Board to evaluate
candidate methods for St. John’s wort: Paula Brown, Nour Eddine Es-Safi, Ikhlas Khan, Elizabeth Mudge,
Klaus Reif, Brian Schaneberg, Maged Sharaf, Darryl Sullivan, and Roy Upton. Shauna Roman was vetted
as the St. John’s wort Expert Review Panel Chair and the Official Methods Board liaison. The approved
candidates have previously participated in AOAC activities, including but not limited to, the Methods
Committee on Dietary Supplements, Dietary Supplements Community, Dietary Supplements Task Group,
and the working group for St. John’s wort.
ERP Orientation:
The AOAC Expert Review Panel Orientation Webinar was held on Friday, November 1, 2013.
Standard Method Performance Requirements (SMPRs):
The St. John’s wort Working Group completed the draft Standard Method Performance Requirements
(SMPRs) in August, 2012. The Stakeholder Panel endorsed the SMPR on March 14, 2013 (AOAC SMPR
2013.001). A copy of the SMPR is shown on the following page.
Conclusion:
The Expert Review Panel reviewed all St. John’s wort methods. The following St. John’s wort method
was approved for First Action Official Method status for the analytes (hypericin and pseudohypericin)
and matrices (plant material and powdered extracts) specified by the method and supported by the
validation report:
SJW- 10: Determination of hypericin and pseudohypericin in St. John’s wort by high-
performance liquid chromatography.
Subsequent ERP Activities:
ERP members will evaluate the method for 2 years. AOAC will build into the system a way of responding
to method developers of submitted methods, to inform them if the ERP requires more data to make a
decision. AOAC will establish a ranking system to provide feedback to method developers for submitted
methods.
ERP PROFILE SUMMARIES
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