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2534-Plat
9:30 am
MAPPING MOTIONS AND STRUCTURE TO A STATE NECESSARY FOR
OLIGOMERIZATION OF A LARGE GTPASE: A JOINT SAXS, NSE, EPR AND
FRET STUDY.
Thomas-Otavio Peulen
, Carola S. Hengstenberg, Ralf Biehl,
Mykola Dimura, Alessandro Valeri, Semra Ince, Tobias Vöpel, Bela Farago,
Holger Gohlke, Christian Herrmann, Johann Klare, Andreas Stadler, Claus
A.M. Seidel
2535-Plat
9:45 am
TONB BINDING PRODUCES ALLOSTERIC CHANGES IN THE OUTER LOOPS
AND SUBSTRATE BINDING SITE OF THE TBDT BTUB.
Arthur K. Sikora
,
David Cafiso
2536-Plat
10:00 am
CONFORMATIONAL DYNAMICS AND STRUCTURE UNDERLIE THE NOVEL
LIGAND BINDING SPECIFICITY OF A TIAM1 PDZ DOMAIN MUTANT.
Ernesto J. Fuentes
, Xu Liu, David C. Speckhard, Tyson R. Shepherd,
Sarah R. Hengel, Liping Liping, C. Andrew Fowler, Lokesh Gakhar
Platform
Protein-Nucleic Acid Interaction
8:15 am - 10:15 am, Room 515A
Co-Chairs
Timothy Craggs, University of Oxford, United Kingdom
Steve Harvey, University of Pennsylvania
2537-Plat
8:15 am
HOW STRUCTURE-SPECIFIC DNA-BINDING PROTEINS RECOGNISE THEIR
SUBSTRATES.
Timothy D. Craggs
, Marko Sustarsic, Majid Mosayebi,
Hendrik Kaju, Johannes Hohlbein, Phillip C. Biggin, Jonathan P.K. Doye,
Achilles N. Kapanidis
2538-Plat
8:30 am
FLIPPING BY DNA BOUND PROTEINS OCCURS THROUGH RAPID REBIND-
ING.
Mahipal Ganji
, Margreet Docter, Stuart F.J. Le Grice, Elio
Abbondanzieri
2539-Plat
8:45 am
STEPWISE NUCLEOSOME TRANSLOCATION BY RSC REMODELING COM-
PLEXES.
Bryan T. Harada
, William L. Hwang, Sebastian Deindl, Blaine
Bartholomew, Xiaowei Zhuang
2540-Plat
9:00 am
PROBING HELICASE DYNAMICS ON NUCLEIC ACIDS THROUGH FLUORES-
CENCE-FORCE MEASUREMENTS.
Chang-Ting Lin
, Meigang Gu, Charles
M. Rice, Virginia A. Zakian, Taekjip Ha Ha
2541-Plat
9:15 am
THE SCRUNCHWORM HYPOTHESIS: TRANSITIONS BETWEEN A-DNA
AND B-DNA PROVIDE THE DRIVING FORCE FOR GENOME PACKAGING IN
DOUBLE-STRANDED DNA BACTERIOPHAGES.
Stephen C. Harvey
, James
T. Waters, James C. Gumbart, Harold D. Kim
2542-Plat
9:30 am
TFAM REGULATES MITOCHONDRIAL TRANSCRIPTION THROUGH
SEQUENCE-SPECIFIC DNA LOOPING.
Divakaran Murugesapillai
, Maria F.
Lodeiro, Louis J. Maher III, Craig E. Cameron, Mark C. Williams
2543-Plat
9:45 am
VISUALIZING THE ASSEMBLY OF DNA CONDENSATION CLUSTERS BY SMC
USING SINGLE-MOLECULE MICROSCOPY.
Hyeongjun Kim
, Joseph J.
Loparo
2544-Plat
10:00 am
SINGLE MOLECULE IMAGING OF P53’S DYNAMIC INTERACTION WITH
CHROMATIN. Vincent Wong, Zhe Liu, Sam Peng, Charles Kenworthy,
Wei-Li Liu,
Robert A Coleman
Platform
Force Spectroscopy and Scanning Probe
Microscopy
8:15 am - 10:15 am, Room 515B
Co-Chairs
Pieter De Beule, International Iberian Nanotechnology Laboratory,
Portugal
A. Catalina Velez-Ortega, University of Kentucky
2545-Plat
8:15 am
ACOUSTIC FORCE SPECTROSCOPY: AN INSTRUMENT TO PERFORM
HIGHLY PARALLEL SINGLE MOLECULE MEASUREMENTS.
Gerrit Sitters
,
Felix Oswald, Douwe Kamsma, Jerom Langeveld, Willem Peutz, Erwin
Peterman, Gijs Wuite, Olivier Heyning
2546-Plat
8:30 am
A NOVEL METHOD FOR MULTIPLEXED NANOMETRIC BEAD TRACKING.
Thomas Brouwer
, John van Noort
2547-Plat
8:45 am
SIMULTANEOUS ADVANCED MICROSCOPIES FOR LIVE CELL SIGNALING
DYNAMICS INVESTIGATIONS. Adelaide Miranda, Marco Martins,
Pieter
A. A. De Beule
2548-Plat
9:00 am
VIDEO-BASED FORCE DETECTION IN OPTICAL TWEEZERS TO MEASURE
DNA TRANSLOCATION THROUGH SI-NX AND LIPID-COATED NANOPORES.
Andy Sischka
, Sebastian Knust, Lukas Galla, Andreas J. Meyer, Andre
Spiering, Michael Mayer, Adam R. Hall, Peter Reimann, Karsten Gall, Dario
Anselmetti
2549-Plat
9:15 am
ADAPTIVE HOPPING PROBE ION CONDUCTANCE MICROSCOPY OF LIVE
CELLS AT ~5-10 NM RESOLUTION.
A. Catalina Velez-Ortega
, Oleg Belov,
Pavel Novak, Samir A. Rawashdeh, Yuri E. Korchev, Gregory I. Frolenkov
2550-Plat
9:30 am
DIRECT OBSERVATION OF TRANSITION PATHS DURING THE FOLDING
OF PROTEINS AND NUCLEIC ACIDS. Krishna Neupane, Daniel AN Foster,
Derek R. Dee, Hao Yu, Feng Wang,
Michael T. Woodside
2551-Plat
9:45 am
EQUILIBRIUM FOLDING OF AN INDIVIDUAL BACTERIORHODOPSIN INTO
AND OUT OF ITS NATIVE LIPID BILAYER RESOLVES ENERGY LANDSCAPES
AND HIDDEN DYNAMICS.
Hao Yu
, Matthew G. W. Siewny, Devin T.
Edwards, Aric W. Sanders, Thomas T. Perkins
2552-Plat
10:00 am
BINDING MECHANISM OF PURINE NUCLEOTIDES TO MITOCHONDRIAL
UNCOUPLING PROTEINS EXPLORED BY RECOGNITION FORCE SPECTROS-
COPY.
Melanie Koehler
, Gabriel Macher, Anne Rupprecht, Rong Zhu,
Hermann J. Gruber, Elena E. Pohl, Peter Hinterdorfer
Platform
Biosensors
8:15 am - 10:15 am, Room 501ABC
Co-Chairs
Loredana Casalis, Elettra Sincrotrone Trieste, Italy
Sergey Sekatskii, École Polytechnique Fédérale de Lausanne, Switzerland
2553-Plat
8:15 am
INTERNATIONAL TRAVEL AWARDEE
CONTROLLING THE NANOSCOPIC CONFINEMENT OF ENZYMES INSIDE
CLYA NANOPORES FOR SINGLE-PROTEIN STUDIES.
Annemie Biesemans
,
Misha Soskine, Giovanni Maglia