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Platform
Molecular Dynamics II
1:00 pm - 3:00 pm, Room 502A
Co-Chairs
Tristan Bereau, Max Planck Institute for Polymer Research, Germany
Tobin Sosnick, University of Chicago
2576-Plat
1:00 pm
RNA CONFORMATIONAL ENSEMBLES: NARROWING THE GAP BETWEEN
EXPERIMENTS AND SIMULATIONS WITH METADYNAMICS.
Alejandro
Gil-Ley
, Sandro Bottaro, Giovanni Bussi
2577-Plat
1:15 pm
APPLICATION OF THE STRING AND 2D HAMILTONIAN REPLICA EXCHANGE
UMBRELLA SAMPLING METHODS FOR THE STUDY OF CONFORMATIONAL
CHANGES IN THE BACTERIAL ASPARTATE TRANSPORTER GLT(PH).
Hristina R. Zhekova
, Bogdan Lev, Sergei Noskov
2578-Plat
1:30 pm
EDUCATION TRAVEL AWARDEE
QUANTIFYING MACROMOLECULAR TRANSITION PATHS WITH PATH SIMI-
LARITY ANALYSIS.
Sean L. Seyler
, Avishek Kumar, Taylor Colburn, Michael
F. Thorpe, Oliver Beckstein
2579-Plat
1:45 pm
INVESTIGATING KINETICS OF CONFORMATIONAL CHANGE USING MOLEC-
ULAR DYNAMICS AND MILESTONING.
Hiroshi Fujisaki
, Ayori Mitsutake
2580-Plat
2:00 pm
IMPROVED KINETICS OF MOLECULAR SIMULATIONS USING BIASED MAR-
KOV STATE MODELS. Joseph F. Rudzinski, Kurt Kremer,
Tristan Bereau
2581-Plat
2:15 pm
UPSIDE: A NEW DYNAMICS METHOD CAPABLE OF COOPERATIVE DE
NOVO PROTEIN FOLDING IN CPU-HOURS.
Tobin R. Sosnick
, John M.
Jumper, Karl F. Freed
2582-Plat
2:30 pm
MODELLING CYSTEINE DISULFIDE EXCHANGE REACTIONS BY MOLECULAR
DYNAMICS SIMULATIONS.
Katra Kolšek
, Camilo Aponte-Santamaría,
Frauke Gräter
2583-Plat
2:45 pm
CLASSICAL DENSITY FUNCTIONAL THEORY FOR IMPLICIT SOLVENT SIMU-
LATIONS.
Eric A. Mills
, Steven S. Plotkin
Platform
Cardiac Muscle Regulation
1:00 pm - 3:00 pm, Room 502B
Co-Chairs
Nazha Hamdani, Ruhr University Bochum, Germany
Alla Kostyukova, Washington State University
2584-Plat
1:00 pm
DOES TROPOMYOSIN SLIDE OR ROLL OVER F-ACTIN DURING REGULA-
TORY TRANSITIONS? Michael Rynkiewicz, Veronika Schott, Marek
Orzechowski, Stefan Fischer,
William Lehman
2585-Plat
1:15 pm
TROPOMYOSIN DYNAMICS DURING CARDIAC THIN FILAMENT ACTIVA-
TION AS GOVERNED BY A MULTI-WELL ENERGY LANDSCAPE.
Yasser
Aboelkassem
, Natalia Trayanova
2586-Plat
1:30 pm
INVESTIGATING COOPERATIVITY USING A NEW BIOPHYSICALLY DETAILED
CARDIAC CONTRACTION MODEL.
Sander Land
, Steven A. Niederer
2587-Plat
1:45 pm
CARDIOMYOPATHY-ASSOCIATED MUTATION K15N IN TROPOMYOSIN AF-
FECTS ITS INTERACTION WITH LEIOMODIN AND TROPOMODULIN. Mert
Colpan, Dmitri Tolkatchev, Samantha Grover, Gregory L. Helms, John R.
Cort, Natalia Moroz,
Alla S. Kostyukova
2588-Plat
2:00 pm
INTEGRATION OF CARDIAC TROPONIN I PHOSPHORYLATIONS TO MODU-
LATE FUNCTION.
Hussam E. Salhi
, Nicholas P. Gualtieri, Shane D. Walton,
Elizabeth A. Brundage, Jonathan P. Davis, Brandon J. Biesiadecki
2589-Plat
2:15 pm
CROSSTALK WITHIN CARDIAC TROPONIN COMPLEX WITH THE R145W
MUTATION IN CARDIAC TROPONIN I.
Nikolai Smolin
, Alexey V. Dvornikov,
Jodi L. Martin, Seth L. Robia, Pieter P. de Tombe
2590-Plat
2:30 pm
CMYBP-C PHOSPHORYLATION MODULATES SARCOMERE LENGTH-
DEPENDENT CHANGES IN CARDIAC MUSCLE CONTRACTILE FUNCTION.
Ranganath Mamidi
, Kenneth S. Gresham, Julian E. Stelzer
2591-Plat
2:45 pm
IMPACT OF CGMP-PKG PATHWAY MODULATION ON TITIN PHOSPHORYLA-
TION AND TITIN-BASED MYOCARDIAL PASSIVE STIFFNESS.
Nazha
Hamdani
, Melissa Herwig, Soraya Heopler, Doris Koesling, Marcus
Kreuger, Michaela Kuhn, Wolfgang A. Linke
Platform
Ion Channels, Pharmacology, and Disease
1:00 pm - 3:00 pm, Room 515A
Co-Chairs
Aurelia Honerkamp-Smith, University of Cambridge, United Kingdom
Harley Kurata, University of Alberta, Canada
2592-Plat
1:00 pm
POSITIVE ALLOSTERIC MODULATION OF SK CHANNELS BY RILUZOLE.
Young-Woo Nam, Sara Ali, Stephen Chiang, Tia Alexander,
Miao Zhang
2593-Plat
1:15 pm
DEFINING THE MOLECULAR MECHANISMS OF SUBTYPE SPECIFIC
KCNQ2/3 POTASSIUM CHANNEL ACTIVATORS.
Wei-Ting (Alice) Wang
,
Michael Yau, Harley Kurata
2594-Plat
1:30 pm
VOLTAGE-DEPENDENT ACCESSIBILITY OF PHOSPHORYLATION SITES AT
THE CARBOXY-TERMINAL DOMAIN OF KV1.3 CHANNELS DETERMINES
KV1.3-INDUCED CELL PROLIFERATION.
Teresa Pérez-García
, Pilar Cidad,
Laura Jiménez-Perez, Ines Alvarez-Miguel, Alba Santos-Hipolito,
Esperanza Alonso, Miguel A. de la Fuente, José R. López-López
2595-Plat
1:45 pm
USING UNNATURAL AMINO ACIDS TO PROBE THE MOLECULAR BASIS
FOR HERG DRUG BLOCK.
Logan Macdonald
, Robin Y. Kim, Harley T.
Kurata, Christopher Ahern, David Fedida
2596-Plat
2:00 pm
MANUAL PATCH-CLAMP RECORDING FOR MEDIUM-THROUGHPUT ION
CHANNEL DRUG SCREENING: ASSAY VALIDATION BY SEARCHING FOR
A BLOCKER OF NUCLEAR MONOVALENT CATIONIC CHANNEL.
Viktor
Yarotskyy
, Robert T. Dirksen
2597-Plat
2:15 pm
ON THE RELATION BETWEEN HERG CHANNEL BLOCK IN CELL LINE AND
ACTION POTENTIAL PROLONGATION IN HUMAN IPSC CARDIOMYOCYTES.
Priyanka Saxena
, Maria Hortigon-Vinagre, Stanislav Beyl, Igor Baburin,