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496-Pos
Board B276
INTERNATIONAL TRAVEL AWARDEE
MECHANICAL REGULATION OF NUCLEAR SHAPE AND VOLUME.
Dong-
Hwee Kim
, Bo Li, Fangwei Si, Jude Phillip, Denis Wirtz, Sean X. Sun
497-Pos
Board B277
MECHANOSENSING DEFECTS IN NUCLEAR ENVELOPE RELATED DISOR-
DERS. Christine Technau, Martina Fischer, Kamel Mamchaoui, Anne Bigot,
Thevy Lok, Claude Verdier, Alain Duperray, Thomas Voit, Susana Quijano-
Roy, Gisèle Bonne,
Catherine Coirault
498-Pos
Board B278
CYCLIC STRAIN OF PRECISION CUT LUNG SLICES (PCLS) INDUCES PRO-
INFLAMMATORY AND PRO-PROLIFERATIVE SIGNALLING.
David Salman
,
Charlotte Dean, Mark J. D Griffiths
Excitation-Contraction Coupling I
(Boards B279 - B301)
499-Pos
Board B279
RYANODINE RECEPTOR SENSITIVITY GOVERNS THE STABILITY AND
SYNCHRONY OF LOCAL CALCIUM RELEASE DURING CARDIAC EXCITATION-
CONTRACTION COUPLING.
Andrew P. Wescott
, M. Saleet Jafri, W.
Jonathan Lederer, George S. B. Williams
500-Pos
Board B280
DANTROLENE INHIBITION OF SKELETAL MUSCLE RYR IN THE PRESENCE
OF CAM.
Ye W. Oo
, M.S Imtiaz, D.F. vanHelden, D.R Laver
501-Pos
Board B281
NOVEL COMPOUNDS INHIBIT CALMODULIN DEFICIENT RYR2 ACTIVITY
AND ARRHYTHMIAS IN A CPVT MOUSE MODEL.
Robert C. Klipp
, Na Li,
Qiongling Wang, Martha Sibrian-Vazquez, Robert M. Strongin, Xander H.T.
Wehrens, Jonathan J. Abramson
502-Pos
Board B282
INTERNATIONAL TRAVEL AWARDEE
S4-S5 LINKER REGULATES RYR2 CHANNEL GATING THROUGH MULTIPLE
INTERACTIONS.
Takashi Murayama
, Nagomi Kurebayashi, Haruo Ogawa,
Junji Suzuki, Kazunori Kanemaru, Masamitsu Iino, Takashi Sakurai
503-Pos
Board B283
SPONTANEOUS AND VOLTAGE-ACTIVATED ELEMENTARY CALCIUM
RELEASE EVENTS IN INTACT SKELETAL MUSCLE FIBERS EXPRESSING THE
EMBRYONIC CAV1.1 SPLICE VARIANT.
Beatrix Dienes
, János Vincze, Péter
Szentesi, Nasreen Sultana, Berhnard E. Flucher, László Csernoch
504-Pos
Board B284
CHARACTERIZATION OF THE STAC3-CAV1.1 INTERACTION IN SKELETAL
MUSCLE EXCITATION-CONTRACTION COUPLING.
Marta Campiglio
,
Bernhard E. Flucher
505-Pos
Board B285
THE TRANSMEMBRANE DOMAIN IS SUFFICIENT TO DIRECT JUNC-
TOPHILIN-1 LOCALIZATION AT THE JUNCTIONAL SR.
Daniela Rossi
, Angela
Maria Scarcella, Stefania Lorenzini, Vincenzo Sorrentino
506-Pos
Board B286
CELLULAR PATHOPHYSIOLOGY OF “MHH”, A LARGE GROUP OF PATIENTS
WITH EQUIVOCAL DIAGNOSIS OF MALIGNANT HYPERTHERMIA.
Lourdes
Figueroa
, Carlo Manno, Natalia Kraeva, Sheila Toro, Eduardo Rios, Sheila
Riazi
507-Pos
Board B287
THE MALIGNANT HYPERTHERMIA RYR1Y522S MUTATION AFFECTS CAL-
CIUM HOMEOSTASIS IN ARTERIAL SMOOTH MUSCLE CELLS. Ruben Lopez,
Susan N. Treves,
Francesco Zorzato
508-Pos
Board B288
INACTIVATION OF CAV1.1 CHANNELS IN ADULT SKELETAL MUSCLE: EF-
FECTS OF A C-TERMINAL PRE-IQ MUTATION.
Erick O. Hernández-Ochoa
,
Brian R. Cannon, Camilo Vanegas, David J. Weber, Martin F. Schneider
509-Pos
Board B289
STIM1-DEPENDENT CA2+ SIGNALING IN CARDIAC MYOCYTES. Cory Parks,
Ryan Sullivan,
Salvatore Mancarella
510-Pos
Board B290
MODELING THE ROLE OF NCX IN THE REGULATION OF CARDIOMYO-
CYTE MICRODOMAIN CA
2+
DYNAMICS.
Lulu Chu
, Joseph L. Greenstein,
Raimond L. Winslow
511-Pos
Board B291
TRANSMURAL DIFFERENCES IN PRELOAD-DEPENDENCY OF CA
2+
TRAN-
SIENTS IN ISOLATED CARDIOMYOCYTES.
Anastasia Khokhlova
, Gentaro
Iribe, Olga Solovyova
512-Pos
Board B292
THE TRPV4 ION CHANNEL ALTERS INTRACELLULAR CALCIUM TRANSIENTS
IN CARDIOMYOCYTES OF AGED MICE.
John L. Jones
, Michelle D. Lambert,
Justin T. Whitfield, Timothy L. Domeier
513-Pos
Board B293
THE CONCENTRATIONS OF TOTAL CALCIUM IN FAST-TWITCH AND HEART
MUSCLES FROMMICE IN AN AGITATED AND ACTIVE STATE IS ALMOST
2-FOLD GREATER THAN THOSE FROM RESTING MICE. Abby F. McDonell,
Paul C. Pape
514-Pos
Board B294
CA2+ TIDES IN CARDIOMYOCYTES UNDER MECHANICAL LOADING.
Zhong
Jian
, Leighton T Izu, Yi-Je Chen, Brittani Wood, Julie Bossuyt, Kit S Lam, Ye
Chen-Izu
515-Pos
Board B295
DYSSYNCHRONOUS CA REMOVAL IN ATRIAL CARDIAC MYOCYTES.
Felix
Hohendanner
, Frank Heinzel, Lothar Blatter
516-Pos
Board B296
INTEPLAY OF TRIGGER CA
2+
WAVES AND CA
2+
TRANSIENT ALTERNANS IN
ATRIAL MYOCYTES.
Gary Aistrup
, Yohannes Shiferaw, Rishi Arora, Georg
Gussak, Soren Grubb, WilliamMarszalec, J. AndrewWasserstrom
517-Pos
Board B297
ACTIVATION OF REVERSE NA/CA EXCHANGER BY SKELETAL NA CHANNEL
ISOFORM INCREASES EXCITATION-CONTRACTION COUPLING EFFICIENCY
IN RABBIT CARDIOMYOCYTES.
Natalia S. Torres
, John HB Bridge
518-Pos
Board B298
USING ACTION POTENTIAL CLAMP DATA TO DETERMINE THE CALCIUM
FLUXES AND CONTRIBUTIONS IN EXCITATION-CONTRACTION COUPLING
IN VIVO IN CARDIOMYOCYTES.
Martin Laasmaa
, Marko Vendelin, Rikke
Birkedal
519-Pos
Board B299
CHARACTERIZATION OF TWO HUMAN SKELETAL CALSEQUESTRIN MU-
TANTS IMPLICATED IN MALIGNANT HYPERTHERMIA AND VACULOLAR
AGGREAGTES MYOPATHY.
Eduardo Rios
, Kevin M. Lewis, Leslie A. Ronish,
ChulHee Kang
520-Pos
Board B300
IMAGING STUDIES OF CALSEQUESTRIN STRUCTURE IN SKELETAL MUSCLE.
EFFECTS OF CALCIUM RELEASE.
Eduardo Rios
, Carlo Manno, Lourdes
Figueroa, Clara Franzini-Armstrong
521-Pos
Board B301
MECHANICAL ANALYSIS OF SINGLE MYOCYTE CONTRACTION IN A 3D
VISCOELASTIC GEL.
John A. Shaw
, Alan Wineman, Rafael Shimkunas,
Leighton Izu, Ye Chen-Izu