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548-Pos
Board B328
WHAT DETERMINES THE CHARYBDOTOXIN SPECIFICITY AMONG KV1
POTASSIUM CHANNELS?
Drew C. Tilley
, Sarel Fleishman, Jon T. Sack,
Vladimir Yarov-Yarovoy
549-Pos
Board B329
THE MOLECULAR MECHANISM OF THE DUAL SPIDER TOXIN EFFECT ON
VOLTAGE GATED K
+
CHANNELS. Sara Liin, Anders Gabrielsson, Fredrik
Elinder,
Erik Lindahl
550-Pos
Board B330
IN-SILICO ELECTROPHYSIOLOGY: ON THE ACTIVATION OF VOLTAGE-GATED
ION CHANNELS USING MOLECULAR DYNAMICS SIMULATIONS.
Mounir
Tarek
, Lucie Delemotte, Marina Kasimova, Michael L. Klein, Vincenzo
Carnevale
551-Pos
Board B331
INSERTION OF CROSSLINKABLE AMINO ACIDS INTO THE I
KS
CHANNEL
COMPLEX DEMONSTRATES A VARIABLE KCNQ1:KCNE1 STOICHIOMETRY
OF UP TO 4:4.
Maartje F.E. Westhoff
, Christopher I. Murray, Emely
Thompson, Robert Emes, Jodene Eldstrom, David Fedida
Voltage-gated Na Channels I
(Boards B332 - B361)
552-Pos
Board B332
MOLECULAR SCALE PREDICTION OF LIDOCAINE INTERACTION WITH THE
PORE DOMAIN OF HUMAN NAV1.5.
Kevin DeMarco
, Céline Boiteux, Toby
W. Allen, Vladimir Yarov-Yarovoy, Colleen E. Clancy
553-Pos
Board B333
A COMPUTATIONAL MODELING INVESTIGATION INTO SCN10A LINKED
BRUGADA SYNDROME.
Marcus Vincent
, Pei-Chi Yang, Colleen E. Clancy
554-Pos
Board B334
FACILITATION OF RAPID TEMPORAL PROCESSING BY ION CHANNEL COOP-
ERATIVITY SUGGESTS COORDINATION THROUGH MEMBRANE ELECTRO-
MECHANICS.
Mussie K. Araya
, William E. Brownell
555-Pos
Board B335
COMPUTATIONAL MODELING OF SODIUM CHANNEL INACTIVATION.
Kin
Lam
, Zhe Wu, Klaus Schulten
556-Pos
Board B336
MOLECULAR DYNAMICS SIMULATIONS OF THE OPEN STATE STRUCTURE
OF A BACTERIAL VOLTAGE-GATED SODIUM CHANNEL REVEAL THE BIND-
ING MECHANISMS OF CHANNEL BLOCKERS.
Song Ke
, B. Ann Wallace,
Jakob P. Ulmschneider, Martin B. Ulmschneider
557-Pos
Board B337
COMPUTATIONAL STUDY OF BINDING OF μ-CONOTOXIN GIIIA (μ-CTX) TO
NAVRH AND NAVAB.
Dharmeshkumar J. Patel
558-Pos
Board B338
BINARY ARCHITECTURE OF THE NAV1.2-β2 SIGNALING COMPLEX.
John
M. Gilchrist
, Samir Das, Filip Van Petegem, Frank Bosmans
559-Pos
Board B339
STRUCTURAL COMPARISONS OF IMMUNOGLOBULIN FOLDS OF HUMAN
NAVβ SUBUNITS.
Samir Das
, John Gilchrist, Frank Bosmans, Filip Van
Petegem
560-Pos
Board B340
CALMODULIN AND FIBROBLAST GROWTH FACTOR HOMOLOGOUS
FACTOR CO-REGULATION OF THE NAV1.5 CHANNEL IN LQT3 MUTA-
TIONS.
Chaojian Wang
, Haidun Yan, Geoffrey S. Pitt
561-Pos
Board B341
INTRACELLULAR CALCIUM DIFFERENTIALLY AFFECTS SCN5A MIXED SYN-
DROME MUTATIONS.
Mena Abdelsayed
, Peter C. Ruben
562-Pos
Board B342
STRUCTURAL DIFFERENCES IN CALMODULIN BOUND TO VOLTAGATE-
GATED SODIUM CHANNEL IQ MOTIFS.
Ryan Mahling
, C. Andrew Fowler,
Liam Hovey, Liping Yu, Lokesh Gakhar, Zesen Lin, Nisha Pandey, Toni
Martins, Madeline A. Shea
563-Pos
Board B343
FUNCTIONAL MODIFICATION OF BACTERIAL VOLTAGE-GATED SODIUM
CHANNELS BY BATRACHOTOXIN.
Rocio K. Finol-Urdaneta
, Jeffrey R.
McArthur, Rachelle Gaudet, Robert J. French
564-Pos
Board B344
MECHANOSENSITIVITY OF THE BACTERIAL VOLTAGE-GATED SODIUM
CHANNEL NACHBAC.
Constanza A. Alcaino
, Peter R. Strege, Cheryl E.
Bernard, Gianrico Farrugia, Arthur Beyder
565-Pos
Board B345
EFFECTS OF LATE SODIUM CURRENT (INAL) BLOCKADE DURING ACUTE
MYOCARDIAL ISCHEMIA.
Carlotta Ronchi
, Marcella Rocchetti, Eleonora
Torre, Riccardo Rizzetto, Joyce Bernardi, Gaspare Mostacciulo, Antonio
Zaza
566-Pos
Board B346
NOVEL STORM-BASED QUANTITATIVE ASSESSMENT OF RELATIVE
PROTEIN LOCALIZATION REVEALS NEW ROLE FOR SODIUM CHANNEL β1
SUBUNIT IN CARDIAC CONDUCTION.
Rengasayee Veeraraghavan
, Robert
G. Gourdie
567-Pos
Board B347
BIOPHYSICAL AND PHARMACOLOGICAL CHARACTERIZATION OF MUL-
TIPLE NAV SUBTYPES ON QUBE.
Mads P. Korsgaard
, Anders Lindqvist,
Søren Friis, Mette T. Christensen
568-Pos
Board B348
CYSTEINE RESIDUES C489 AND C1135 OF NAV 1.5 PLAY A CRITICAL ROLE
IN PRODUCING LATE SODIUM CURRENT THROUGH NNOS-DEPENDENT
S-NITROSYLATION OF NAV 1.5.
Jianding Cheng
, John W. Kyle, Graham S.
Adsit, Carmen R. Valdivia, Alyson K. Fisher, Jonathan C. Makielski
569-Pos
Board B349
MODULATION OF A BACTERIAL VOLTAGE-GATED SODIUM CHANNEL BY
THE ANTI-EPILEPTIC DRUG LACOSAMIDE. Celine Boiteux,
Chris French
,
Toby W. Allen
570-Pos
Board B350
PATIENT-SPECIFIC INDUCED PLURIPOTENT STEM CELL CARDIAC MYO-
CYTES AS PREDICTORS OF SUDEP RISK.
Chad R. Frasier
, Helen Zhang,
James Offord, David S. Auerbach, Jack M. Paren, Lori L. Isom
571-Pos
Board B351
BIOPHYSICAL, MOLECULAR AND PHARMACOLOGICAL CHARACTERIZA-
TION OF NAV CHANNELS FROM INDUCED PLURIPOTENT STEM CELLS
DERIVED CARDIOMYOCYTES.
Aurélie Mercier
, Adrien Moreau, Olivier
Thériault, Mohamed Chahine
572-Pos
Board B352
MICE WITH A NULL ALLELE FOR NAV1.4 EXHIBIT PSEUDO-MYASTHENIA,
BUT ARE NOT SUSCEPTIBILE TO PERIODIC PARALYSIS. Fenfen Wu, Wentao
Mi, Yu Fu,
Steve C. Cannon
573-Pos
Board B353
SCN4A PORE MUTATION PATHOGENETICALLY CONTRIBUTES TO AUTOSO-
MAL DOMINANT ESSENTIAL TREMOR AND MAY INCREASE SUSCEPTIBIL-
ITY TO EPILEPSY. Alberto Bergareche,
Marcin J. Bednarz
, Elena Sánchez,
Catharine E. Krebs, Javier Ruiz-Martinez, Patricia De la Riva, Vladimir
Makarov, Ana Gorostidi, Karin Jurkat-Rott, Jose Felix Marti-Masso, Coro
Paisán-Ruiz