1058 / 1674
APBI with 3D-CRT vs. IMRT
(63 patients)
Rusthoven et al. IJROBP 70:296-302. 2008
3D-CRT
%
IMRT
%
Reduction
%
CTV V95
98.4
98.2
0.2
PTV V95
96.0
88.8
8
Ipsilat. nontarget
breast V50
34.5
28.1
19
Ipsilat. nontarget
breast V100
5.8
0.4
93
Ipsilat. lung
V20Gy
2.3
1.2
48
Heart V5Gy
1.7
0.6
65
-
IMRT improves normal tissue sparing
in the ipsilateral breast without compromising
dose delivery to clinical target volume
-
IMRT
has more advantages in patients with
more challenging anatomy
, such as smaller
breast size, a larger PTV/breast ratio, or tumors in the vicinity of the heart