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Molecular pathology
ROS
(Reactive
Oxygen
Species)
Cascade of
cytokine
activity
Fibrosis
Superoxide dismutases
Metallothioneins
Ionizing
radiation
CTGF
family
e.g. TGFβ1
(SMADs)
Others
Others
Others
TGFβ1
Adlican, Lumican,
Fibroblast activating protein
WISP2
TNF
α
Alsner, Andreassen et al (2008) Sem Radiat Oncol 18:125-132