Diapositive 1

1414 / 1674

Days
0 25 50 75 100125150175200225
Severe fibrosis (%)
0
20
40
60
80
100
Control (N=14)
+/- buffer or
siRNA mismatch
P=0.00003
siRNA TNFa
(N=11)
Reduced
morbidity
Dose (Gy)
35 40 45 50 55 60 65 70
Response (%)
0
10
20
30
40
50
60
70
80
90
100
siRNA
Control
TCD50 (95% CI)
Enhancement ratio (95% CI)
0.97 (0.88-1.08)
57.8 56.2
Same tumor
response
Nawroth et al. R&O 97: 143-148, 2010