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Difference between models and simulated (TCP

and NTCP) dose-response

dose

systematic

random

(Gy EQD2

a/b

=

10Gy

)

U

s

5% U

r

10% U

r

20%

D

TCP

75

1.0% -0.1% -0.3%

90

0.8% -0.1% -0.3%

(Gy EQD2

a/b

=

3Gy

)

U

s

5% U

r

10% U

r

20% U

r

30%

D

NTCP

65

0.5%

0.1% 1.1% 2.3%

75

1.4%

0.2% 1.6% 3.2%

“Can reduction of uncertainties in cervix cancer brachytherapy potentially

improve clinical outcome?” Nesvacil et al. 2016, submitted to R&O