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reducing random uncertainties can change the slope of the

dose-response relationship observed in a patient cohort

Online image-based treatment delivery verification (reduce time

between treatment simulation and treatment)

Advanced in vivo treatment dose verification

reduction of large systematic uncertainties should be a goal

for OAR and target structures

Contouring uncertainties

Large dose calculation uncertainties (see Luc‘s presentation on

clinical outcome vs. dose calculation algorithm)

Systematic OAR filling changes during treatment (filling

protocols!)