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A heuristic

combining SA & scoring

for the binary part

b

A quasi-Newton

for the

continuous part

t = x²

(optimisation)

30s – 120s

(parallelised, ...)

HIPO: < 240 s (not parallelised)

MILP solver CPLEX: ≈ 48 hrs

< 1.0s

HIPO

MILP

Inverse Planning – using

HIPO

=

=

=

feasible

kASDP

N

k

N

l

i

jkl

lk

K lk k

i

j

d Sxb

d

1

1

,

2

~

(x)

     

) ,

, (

1

w t

r f

fw f

M

m

m m

=

=

=

Minimise