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Small Cell Lung Cancer (SCLC)
Reduced incidence (from 25-30 to 13-15%)
Strongly associated with cigarette smoking
Neuroendocrine features
High frequency of
TP53
and
RB
gene mutations
Highly responsive to CT and RT
High rate of early relapse/PD
Highly aggressive
Often metastasized at the time of diagnosis
Poor cure-rate (10-20%) and overall
prognosis (MS 9-12 months)