1064 / 1851
Neuroendocrine tumors of the lung
Carcinoid
Atypical
Carcinoid
LCNEC SCLC
Mitoses/2mm
2
(10 HPF)
<2
2-10
>10
>10
Smoking
33%
(general population)
64%
98%
97%
5 YR OS
92-100%
61-88%
13-57%
5%
Prevalence
1-2%
0.1-0.2% 1.6-3% 15%
TP53 mutation
6%
-
74%
90%
RB1 down-regulation
0%
21%
68%
87%
MEN mutation
18%
36%
0%
0%
Beasley et al.
Human Pathol
, 2003
Haruki et al.
Jpn J can cer
Res, 2000
Adapted from Swarts et al.
BBA-Rev on Cancer
,2012