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Best Tumor Shrinkage of Patients Enrolled in
Genotype-Matched Trials
P. Bedard et al. AACR 2015
Breast
Colorectal
Lung
Gynecological
Genitourinary
Pancreatobiliary
Upper Aerodigestive
Other
Disease Sites
Genotype
Matched Trials Most Common Mutations
Breast
22
PIK3CA (18)
Colorectal
18
BRAF (8), KRAS (5)
Lung
21
KRAS (11), EGFR (8)
Gynecological
22
KRAS (12), PIK3CA (6)
RECIST v1.1 Overall Response Rate= 20%