Diapositive 1

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Summary
 Inhibition of EGFR in combination with RT
 multiple mechanisms contribute to enhanced radiosensitivity
 From DDR to Repopulation
 Secretome is as mediator of treatment resistance
 AXL is a promising target for combined radiochemotherapy
 Differential secretome analysis is a promising approach to identify predictive
markers and novel targets for radiosensitization.
 Novel ADAM17 inhibitors are promising agents to improve the radiotherapy
outcome of NSCLC.