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Effect of TMI-005 and IR alone and in combination on the
growth of A549-derived tumor xenografts
Tumor Volume
~200mm
3
2x
TMI-005
2x
TMI-005
2x
TMI-005 +
IR (1Gy)
2x
TMI-005
2x
TMI-005
2x
TMI-005 +
IR (1Gy)
2x
TMI-005 +
IR (1Gy)
DAY 1
DAY 2
DAY 3
DAY 4
DAY 5
DAY 6
DAY 7
1 HOUR
AFTER LAST
TREATMENT
Continued
measurements of
tumor volume
IHC
Combined treatment of TMI-005 and IR exerts a supra-additive
tumor growth delay in A549-derived tumor xenografts