1147 / 1851
Ionizing Radiation (IR) induces the secretion of multiple
ADAM substrates
in vitro
and
in vivo
(A549 adenocarcinoma cells)
Negative Control
Normoxia
Hypoxia
Ionizing Radiation
VEGFA
uPA
(In parallel: Screening of patient serum as part of clinical trials)
Amphiregulin
Betacellulin
ALCAM
Sharma A
et al
. Clin. Cancer Research (2016)
Upstream Mechanism: ADAM17