1239 / 1851
HPV/p16 and HNSCC in the oropharynx
• Oropharynx cancer
• Increasing incidence
• Non-keratinizing SCC
• p16 expression, p53wt
• Younger age/more fit
• Less smoking
• Less alcohol
• N+ (advanced disease)
• Improved prognosis
Updated from Lassen 2010
Year
1977 1982
1987 1992 1997 2002 2007 2012 2017
Number of patients
0
50
100
150
200
250
300
350
400
450
Oropharynx
Larynx
70%*
55%*
33%*
42%*
37%*
62%*
65%*
DAHANCA 1977-2014
*HPV/p16+