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Clinical impact of HPV in H&N radiotherapy

DAHANCA

database stage III-IV oropharynx, hypopharynx, larynx

N=1604

HPV/p16 negative

N=1124

HPV/p16 positive oropharynx

N=480

Benefit of

Hypoxic

Modification

Benefit of

Accelerated

Fract.

Benefit of

Chemo-

Radiotherapy

Current standard of care:

Chemo-radiotherapy

(accelerated fx)

Adapted from Overgard and Lassen 2015