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Clinical impact of HPV in H&N radiotherapy
DAHANCA
database stage III-IV oropharynx, hypopharynx, larynx
N=1604
HPV/p16 negative
N=1124
HPV/p16 positive oropharynx
N=480
Benefit of
Hypoxic
Modification
Benefit of
Accelerated
Fract.
Benefit of
Chemo-
Radiotherapy
Current standard of care:
Chemo-radiotherapy
(accelerated fx)
Adapted from Overgard and Lassen 2015