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De-escalation: RTOG 1016: phase III
p16+ oropharyngeal carcinomas
T1-2,N2a-3 or T3-4
any N
RANDOMIZE
RT 70Gy/35f/6 wks + cisplatin 100mg/m² x 2
Stratify:
T 1-2
T3-4
N0-2a
N2b-c
Smoking
Zubrod 1-
2
RT 70Gy/35f/6 wks + cetuximab for 8 weeks
N=700
Reducing toxicity by replacement of cisplatin with cetuximab ?
98 pts recruited before closure in July 2014