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HPV, smoking and risk groups in RTOG 0129

p16pos

- smoking

p16pos

+smoking

(p16neg –

smoking)

p16neg

+smoking

Mixed

etiology?

Ang 2012

The “

pack year”

definition

:

Probably covers a mixture of the

influence of

current smoking

, and a

potential

dual etiology

in patients

with a smoking history