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3 Questions re use of chemotherapy

1. Do you simply want to reduce the risk of local

recurrence (SCPRT or CRT needed)

2. Do you need to shrink the cancer to ensure an R0

resection?

(you can ignore data re irinotecan and biologicals

on postop adjuvant)

3.

Or do you want to reduce micro-metastases?

(you

cant ignore data on postop adjuvant)