1653 / 1851
What is the mechanism of the effect of preoperative
CRT in preventing local recurrence?
1. by treating microscopic areas not seen
(discontinuous deposits) and so not routinely
removed by surgeon ?
2. by treating areas not routinely removed by surgeon
(external iliac nodes/obturator nodes etc..) ?
3. by countering spillage ie rendering cells non-viable
with RT?
4. by countering spillage growing ie tumour bed effect?
5. by compensating for poor surgical technique?
6. by damaging tumour /vasculature and causing
immune effects/loss of tolerance etc..?