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Fractionation sensitivity
Early reacting normal tissues
• Low fractionation
sensitivity
• Small increase in
tolerance with decreasing
dose per fraction
• High alpha-beta (8-30 Gy)
• Time factor (repopulation)
Late reacting normal tissues
• High fractionation
sensitivity
• Large increase in
tolerance with decreasing
dose per fraction
• Low alpha-beta (2-4 Gy)
• No time factor