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High dose per fx increase late radiation damage

ERYTHEMA (ACUTE) FIBROSIS (LATE)

0%

20%

40%

60%

80%

COMPLICATIONS (

%)

Overgaard M et al. 1987

5 Fx

5 Fx

2 Fx

2 Fx

50 Gy / 25 fx

42 Gy / 12 fx