361 / 1851
Cisplatin and RT
Wilson GD 2006
• Increase in toxic platin-derivatives
• Cisplatin blocks DNA-ends
• RT increase cellular uptake of
cisplatin
• Stop cells in the G2-phase
• Impaired repair of DNA
|
|
361 / 1851
Cisplatin and RT
Wilson GD 2006
• Increase in toxic platin-derivatives
• Cisplatin blocks DNA-ends
• RT increase cellular uptake of
cisplatin
• Stop cells in the G2-phase
• Impaired repair of DNA