364 / 1851
”New drugs”
Gemcitabine:
•
Pyrimidin-analogue - interferes with DNA
and inhibits DNA synthesis and repair
• S-phase specific?
Taxanes:
•
Interferes with microtubuli - cell cycle stops
in G2/M-phase
• Synchronizing (only seen
in vitro
)
• Reoxygenation through tumour reduction?