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5-FU and RT
Longley DB 2003
• Thymidin 5-tri-P analogue
• Inhibition of TS
• Deplete Thymidine 5 mono-P
and Thymidine 5 tri-P
• lnhibition of DNA synthesis
• Interference with DNA repair.
• S-phase specific (RT-resistent)
• Inhibit S-phase entry