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I-SPY 2 TRIAL
Taxane +
Herceptin + New
Agent A
Taxane + New
Agent C
Pt is On
Study
Taxane +
Herceptin
Taxane +
Herceptin + New
Agent B
Taxane +
Herceptin + New
Agent C
Taxane
Taxane + New
Agent D
Taxane + New
Agent E
AC
AC
HER 2
(+)
HER 2
(–)
Randomized
Randomized
Surgery
Surgery
Learn, Adapt from
each patient as we
go along
Taxane +
Herceptin + New
Agent F
T xane +
New Agent GH
F