74 / 1851
“Window of Opportunity” Trials
•
Good for:
–
Discovery
–
Proof of principle (e.g.
Johnson presentation)
•
Bad for:
–
Unknown agents
–
? Testing combinatorial
strategies
•
Doses?
•
Toxicity issues
Newly diagnosed pt
Tumor in place
These contribute to scientific knowledge and therapeutic
hypotheses, not clinical care
Short duration
Not intended for therapy
Reprogramming?
Resistance?
Drug Rx