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I-SPY 2 TRIAL

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HER2 (HSP90, HER2, HER3)

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IGFR

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PI3K

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Macrophage

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AKT

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AKT + MAPK, ERBB2, or PI3K+MEK inhibitors

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Death Receptor

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c-MET

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mTOR + X

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Angiogenesis + X

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