Diapositive 1

771 / 1851

ACT I Phase III Trial
Time to Disease by T Stage
Combined
T4
T3
T2
T1
N/K
0 0.25 0.5 0.75 1 1.25 1.5
CMT
103/284 (36%)
25/43 (58%)
41/111 (37%)
26/84 (31%)
7/35 (20%)
4/11 (36%)
RT
(60%) 170/28
(83%) 24/29
(65%) 70/108
(53%) 53/100
(50%) 18/36
(63%) 5/8
CMT betterRT better
0.40
0.38
0.54
0.49
0.52
0.10 1.53
0.16 0.92
0.34 0.86
0.33 0.72
0.30 0.92
0.39 0.63
Stratified by T Stage
0.50