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R

A

N

D

O

M

I

Z

A

T

I

O

N

46 -54Gy in 20-

25 # CRT+ 5FU

45Gy-54 Gy in

20-25 # CRT+

5FU /MMC

N = 291 patients

RTOG 87-04 Trial

9Gy Boost

Reassess with

biopsy and ? boost

after 6 weeks

9Gy Boost