839 / 1851
RT+CT in HR LGG: RTOG 98-02
Buckner JC et al. NEJM 2016;374
251 patients randomly assigned to receive 54 Gy RT alone (126) or 54 Gy RT + adjuvant PCV x 6 (125)
High risk patients according to RTOG criteria:
•
Age<40, with partial resection or biopsy
•
Age>40
Median PFS: 10.4 vs 4 years
p < 0.0001
Median PFS: 13.3 vs 7.8 years
p = 0.002