842 / 1851
IDHmut/1
p
19
q
intact
•
Median PFS:
RT 55.4 months
TMZ 36 months
RT vs TMZ in HR LGG: EORTC 22033
(molecular analysis)
p = 0.0043
IDHmut/1
p
19
q
codel
•
Median PFS:
RT 61.6 months
TMZ 55 months
p = n.s.
IDHwt
•
Median PFS:
RT 19.1 months
TMZ 23.7 months
p = n.s.
CONCLUSION
Our results
might support
the option
of
initial TMZ alone
in good-
prognosis tumors (IDHmut/1
p
19
q
codel), in order
to minimize
the
potential risk of
late toxicity
by
postponing RT (if TMZ could be used
instead) in a patient population who
might live for more than 10–20 years.