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Stupp Regimen: major benefit seen in methylated patients
Patients with GBM containing a methylated MGMT promoter benefited from TMZ
Unmethylated patients did not have such a benefit; for these patients alternative treatments
with different mechanisms of action or methods of inhibiting MGMT shoulf be investigated
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Can we “somehow” overcome TMZ resistance…?
Hegi M. et al. NEJM 2005;352