873 / 1851
Alternative TMZ post-radiation dosing regimens
Regimen
Dose and schedule
Drug exposure
Standard monthly
150-200mg/m
2
x 5d q28d
1
Continuous daily
50mg/m
2
/d
1.8
Continuous (42-49/56-63)
75mg/m
2
/d x 7d/wk for 6 wk
2.1
Alternating (21/28)
85-100 mg/m
2
/d x 21d q 28d
2.6
Alternating weekly (7/14)
135-150 mg/m
2
/d x 7d qow
3.2
Twice daily
200 mg/m
2
(1
st
dose),
90-100 mg/m
2
q12h x 9 doses
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