874 / 1851
Alternative regimens: Alternating TMZ
Dose and schedule
Average decrease in MGMT activity
DAY 7
DAY 14-15
DAY 21
50 to 175 mg/m
2
/day x 7 days
every other week
72%
55%*
50 to 150 mg/m
2
/day x 21 days
with 1 week rest
63%
73%
A
MGMT activity in PBMC after treatment with
temozolomide 7 days on/7days off schedule
B
MGMT activity in PBMC after treatment with
temozolomide 21/28 day schedule
Tolcher AW. et al. Br J Cancer 2003;88
*After 7-day treatment free period