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TMZ alone is not inferior to RT alone in the

treatment of Elderly GBM.

MGMT promoter methylation seems to be a useful

biomarker and could aid decision-making

Elderly patients: TMZ vs RT (NORDIC and NOA-08)

Malmstrom A. et al. Lancet Oncol 2012;13

Wick W. et al. Lancet Oncol 2012;13

60 Gy