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How would you treat this patients ?

A.

High dose Methotrexate

B.

High dose Methotrexate + ARA-C

C.

Rituximab + High dose Methotrexate +

ARA-C + Thiotepa

D.

Rituximab + High dose Methotrexate +

Procarbazine + Vincristine + ARA-C

E.

R-CHOP

F.

Upfront Whole Brain RT