893 / 1851
TWO COURSES
CR, PR, SD
TWO COURSES
WBRT 36 Gy
CR
WBRT 36 Gy
+ boost 9 Gy
PR
SD, PD
PD
Salvage therapy
WBRT
40 Gy
+ boost
9 Gy
MTX 3.5 g/m2
(every 3 weeks)
MTX 3.5 g/m2 + Ara-C 2 g/m2
(every 3 weeks)
Ferreri AJ et al, Lancet 2009; 374
High dose MTX+ARA-C: IELSG20 trial