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Clinical features
Sites of presentation
•
Brain
•
Leptomeninges
•
Eye (PIOL)
•
Spinal cord
Mean age = 60
Gender
: M/F = 1:1
23% ocular involvement
17% positive CSF cytology
Symptoms
•
51% behavioral/personality
•
28% hemiparesis
•
13% seizure
Chemo-radiotherapy is the most commonly used strategy
Efficacy of chemo: limited by special functional and micro-environmental characteristics of the CNS (BBB)
Consolidation after chemotherapy represents the best role for radiotherapy (whole brain RT due to
infiltrative nature of PCNSL)