906 / 1851
Morris PG et. al JCO 2013;31
Chemotherapy schedule R-MVP x 5-7 cycles
•
Rituximab
•
Methotrexate
•
Vincristine
•
Procarbazine
WBRT
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rdWBRT (23.4 Gy/13 fr) in patients who achieved CR
•
Standard WBI (45 Gy/25 fr) in patients with PR-SD-PD
Consolidative CT
•
High dose ARA-Cx 2 cycles
Feasibility of ”reduced dose” WBRT
CR rate: 47%
ORR rate: 95%
Outcomes of patients receiving rdWBRT
Median OS not reached
Median OS 7.7 years