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Toxicity profile of ”reduced dose” WBRT
 At baseline, five of 12 patients had grade ≥ 2 white matter
disease, which decreased to one of 12 after chemotherapy.
 At the 4-year evaluation, the proportion of patients with
white matter changes increased:
 G2 changes  5 patients
 G3 changes  3 patients
 G4-G5 changes  0 patients
WHITE MATTER CHANGES (Fazekas scale)
Morris PG et. al JCO 2013;31