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runt
et al
.:
J
ournal of
aoaC I
nternatIonal
V
ol
.
100, n
o
.
3, 2017
of the lowest standards may be higher. In both laboratories and
for both analytes, the residuals at all but the lowest level are less
than 5%, and at the lowest level, they are below 10%.
LOD and LOQ
NRC established the LOD and LOQ by analyzing the
blank sample Infant Formula Powder, Soy-Based, Lot No.
E10NWZC (Table
2016.14A
, sample No. 16) 14 times (7 days
in duplicate). Minor signals present in the sample were
quantified as fructan, and the average fructan content (on a
reconstituted basis) was determined to be 0.0025 g/100 g with
an SD of 0.0016 g/100 g. The LOD and LOQ were estimated
using the following equations, and the results meet the
requirements in the SMPRs (5).
)
(
=
+ ×
=
LOD 0.0025 3 0.0016 0.0073g 100g
)
(
=
+ ×
=
LOQ 0.0025 10 0.0016 0.018g 100g
Figure 2. Comparison of the method protocols followed by the two different laboratories during the SLV.
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