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Clinical studies
49
Study
(year)
n
Dose
Adaptive strategy Target coverage Normal tissue
sparing
Pos et al.,
(2006)
21
55Gy in 20f (bladder)
(40Gy in 20f pelvis)
or
60Gy in 25f (tumour, 6
patients)
3DCRT
composite from
week 3, for 10-25f
5% repeat CT
scan GTV not
covered by PTV
40% reduction in
PTV
Huddart et al.,
(2011)
26
64-68Gy in 32-34f
(tumour)
50Gy in 25f (bladder)
3DCRT
3 phase sequential
delivery
(adaptive phase 3
plan of the day or
composite)
*V95 98% (plan
of the day), 91%
(composite)
185cm
3
high
dose volume
reduction (plan of
the day) and
220cm
3
(composite)
compared to
conventional
margin approach
Tuomikoski et
al., (2011)
5
45-50.4 Gy in 25-28f
(bladder)
followed by
10-20Gy in 5-10f (tumour)
IMRT
2 phase sequential
delivery
Plan of the day,
phase 1, 3-4 plans;
phase 2, 2-4 plans
V95<100% 3%
(4/121 fractions)
Bowel V45Gy
improved by
155cm
3
compared to
conventional
margin
McDonald et al.,
(2011)
25
36Gy in 6f (bladder)
3DCRT
Plan of the day, 3
plans
*V95 99%
210cm
3
volume
reduction in
tissue receiving
95% dose
compared to
conventional
margin approach