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M (distant spread)
• Spread to areas of the body distant or
remote from the primary tumor.
• Distant metastases are comprised of tumor
cells which have broken away from the
primary tumor and have traveled to other
organs.
• Also called remote, disseminated, diffuse,
metastatic.
• Methods of spread:
•
Travel in lymph channels beyond the first
drainage area
•
Hematogenous or blood-borne metastases
•
Spread through fluids in a body cavity