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Proven benefit:

large ocular melanoma, chordoma/

chondrosarcoma, adenoid cystic carcinoma

Approved applications:

brain tumors (and other tumors

in) children, tumors in proximity to the spinal cord, some

re-irradiations, tumors in which a clear advantage is

expected after plan comparison (Dutch model-based

approach)

Moreover:

Patients with tumors of unclear indication

may be treated in the context of prospective clinical trials

De Ruyssscher et al.

Radiother Oncol

103 : 5, 2012; Allan et al.

Radiother Oncol

103 : 8, 2012; DEGRO website

Guidelines for proton therapy: ESTRO/ASTRO