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RCT (

R

andomised

C

ontrolled

T

rial)

True if main purpose is to

improve efficacy

(local control and survival)

Reduction of radiation-induced side effects?

Randomisation

Standard technique

e.g. IMRT (photons)

New technology

e.g. IMPT (protons)

Courtesy of Hans Langendijk, UMC Groningen

Evidence-based medicine: gold standard